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Cellular aging starts earlier than you think
Must-Have Longevity Supplements
Aging begins as early as our thirties, with cellular and mitochondrial changes that impact longevity.

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The Most Popular Must-Have Longevity Supplements
The most well-researched and widely recommended longevity supplements are those advocated by Dr. David Sinclair, a pioneer in the field of aging and longevity. His core longevity stack includes:
- 1. NMN (Nicotinamide Mononucleotide) ⟶ A precursor to NAD+, crucial for cellular energy and DNA repair.
- 2. Resveratrol ⟶ A polyphenol that activates sirtuins, enhances mitochondrial function, and mimics calorie restriction benefits.
- 3. Fisetin ⟶ A flavonoid known for its senolytic properties, helping remove aging cells.
- 4. Berberine ⟶ Activates autophagy, improves metabolic health, and supports healthy aging.
- 5. Quercetin ⟶ Works synergistically with fisetin to clear senescent cells and support vascular health.
- 6. CoQ10 (Coenzyme Q10) ⟶ Supports mitochondrial energy production and reduces oxidative stress.
- 7. Vitamin D3 + K2 ⟶ Essential for immune health, cardiovascular protection, and calcium metabolism.
Recommended Daily Doses and Timing
Dr. David Sinclair takes his daily dose of NMN and Resveratrol early in the morning, often mixed with yogurt to enhance absorption. Based on his recommendations and available research:
- NMN 500mg - 1g per day
- Resveratrol 500mg - 1g per day
- Fisetin 100mg - 500mg per day
- Spermidine 1mg - 10mg per day
- Quercetin 500mg - 1g per day
- CoQ10 100mg - 200mg per day
- Vitamin D3 + K2 5000 IU D3 + 100 mcg K2 per day
For those who cannot take these supplements on an empty stomach, it is recommended that they be consumed with a meal containing healthy fats. Many longevity supplements are fat-soluble and have better bioavailability when taken with food.
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Purity Concerns: Finding the Best Supplements
NMN has gained immense popularity, but there have been concerns about the purity of NMN supplements sold on the market. Investigations have shown that some brands marketed as NMN were either heavily diluted or ultimately void of NMN. To ensure quality: • Look for third-party tested NMN supplements. • Choose brands that provide certificates of analysis (COA). • Verify purity levels—99% pure NMN is ideal. • Avoid supplements with unnecessary fillers or additives. The Best Longevity Supplements on Amazon and Sinclair-Recommended Options To ensure effectiveness, we have compiled the best NMN and longevity supplements available on Amazon US and Europe, particularly those that align with Dr. Sinclair’s standards. Here are some of the top choices:
Best NMN Brands:
With the advancements in longevity science, these supplements are proving to be essential tools in slowing aging and enhancing health span. Selecting high-quality, research-backed options ensures we get the best possible results for cellular rejuvenation and longevity.
Best NMN Supplements Brands:
- Wonderfeel Youngr NMN 99% Pure NMN, third-party tested, available in the US and Europe.
- Codeage Liposomal NMN NMN + Resveratrol combination for enhanced efficacy.
- Cymbiotika High-potency NMN in capsule form with COA certification.
Best Resveratrol Supplements Brands:
- Toniiq Trans-Resveratrol, micronized for better absorption.
- Life Extension Resveratrol with piperine for enhanced bioavailability.
Best Fisetin & Spermidine Supplements Brands:
- Double Wood Supplements High-purity Fisetin, tested for potency.
- Longevity Labs+ Spermidine-rich wheat germ extract for cellular renewal.
The Science of Aging: When It Really Begins
According to the latest research, aging begins in our thirties—more precisely, from the age of 30-35. At this stage, subtle but significant changes start occurring on a cellular and mitochondrial level, including:
- Decline in NAD+ levels, reducing cellular energy production.
- Mitochondrial dysfunction, leading to reduced efficiency in energy metabolism.
- Telomere shortening, which accelerates cellular aging.
- Increased oxidative stress, causing DNA and protein damage.
- Decreased autophagy, reducing the body’s ability to remove damaged cells.
- Reduced sirtuin activity, impacting longevity-related gene expression.
Given these changes, it is crucial to adopt longevity supplements and a proactive regimen starting in the early thirties to slow down the aging process and optimize cellular health.

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Purity Concerns: Finding the Best Supplements
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What Our Patients Say
“I would not have made it, if it weren’t for my rehab team.”
“Rehabilitation was harder than I expected, but I’m grateful to resume my lifestyle once again.”
“They have been so good to me, I’m so glad they helped me.”